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Analysis of Speech Signals for the Purpose of Neurological Disorders IT Diagnosis
Mekyska, Jiří ; Dostál, Otto (referee) ; Přibilová, Anna (referee) ; Smékal, Zdeněk (advisor)
This work deals with a design of hypokinetic dysarthria analysis system. Hypokinetic dysarthria is a speech motor dysfunction that is present in approx. 90 % of patients with Parkinson’s disease. The work is mainly focused on parameterization techniques that can be used to diagnose or monitor this disease as well as estimate its progress. Next, features that significantly correlate with subjective tests are found. These features can be used to estimate scores of different scales like Unified Parkinson’s Disease Rating Scale (UPDRS) or Mini–Mental State Examination (MMSE). A protocol of dysarthric speech acquisition is introduced in this work too. In combination with acoustic analysis it can be used to estimate a grade of hypokinetic dysarthria in fields of faciokinesis, phonorespiration and phonetics (correlation with 3F test). Regarding the parameterization, features based on modulation spectrum, inferior colliculus coefficients, bicepstrum, approximate and sample entropy, empirical mode decomposition and singular points are originally introduced in this work. All the designed techniques are integrated into the system concept in way that it can be implemented in a hospital and used for a research on Parkinson’s disease or its evaluation.
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Acoustic analysis of sentences complicated for articulation in patients with Parkinson's disease
Kiska, Tomáš ; Smékal, Zdeněk (referee) ; Mekyska, Jiří (advisor)
This work deals with a design of hypokinetic dysarthria analysis system. Hypokinetic dysarthria is a speech motor dysfunction that is present in approx. 90 % of patients with Parkinson’s disease. Next there is described Parkinson's disease and change of the speech signal by this disability. The following describes the symptoms, which are used for the diagnosis of Parkinson's disease (FCR, VSA, VAI, etc.). The work is mainly focused on parameterization techniques that can be used to diagnose or monitor this disease as well as estimate its progress. A protocol of dysarthric speech acquisition is described in this work too. In combination with acoustic analysis it can be used to estimate a grade of hypokinetic dysarthria in fields of faciokinesis, phonorespiration and phonetics (correlation with 3F test). Regarding the parameterization, new features based on method RASTA. The analysis is based on parametrization sentences complicated for articulation. Experimental dataset consists of 101 PD patients with different disease progress and 53 healthy controls. For classification with feature selection have selected method mRMR.
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Design and realization of the vocal encoder for audio electronics
Milota, Vojtěch ; Šotner, Roman (referee) ; Kratochvíl, Tomáš (advisor)
This work deals with the design of the vocal encoder, a device used for regressive synthesis of a speech signal using an external carrier signal. Work consists of the block chart, its breakdown and following design of all partial circuit solutions, including simulations in the software environment, followed by design of the printed circuit board and realisation of a prototype of the vocal encoder, followed by experimental measurement of its properties.
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Assessing movement of articulatory organs based on acoustic analysis of speech
Novotný, Kryštof ; Galáž, Zoltán (referee) ; Mekyska, Jiří (advisor)
Hypokinetic dysarthria is a motor speech disorder often present during Parkinson’s disease. It affects the speech system, including articulatory abilities. There are several speech parameters describing this domain, so it is suggested to deal with their mutual comparison. This work aims to design and describe an algorithm for calculating the parameters of articulation, adapted for the Czech language, and then compare their discriminative power. The acoustic analysis of speech included in it is done via the Praat program and basic machine learning algorithms such as Expectation-Maximization, Kmeans and linear regression are used for the subsequent data processing. The Mann-Whitney U test and representatives of linear, nonlinear and ensemble machine learning models using cross-validation and balanced accuracy are used for evaluation. The results are scripts for automatic assessment of vowel space area, for calculating articulation parameters and for their evaluation. The outputs of the analysis of two different databases (PARCZ and CoBeN) prove that differences in articulation can indeed be observed between normal and dysarthric speech. Based on the mutual comparison of results, it is therefore proposed in the work which parameters and models of machine learning are being appropriate for further dealing with this issue.
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Analysis of speech disorders in patients with a high risk of developing Lewy body diseases
Novotný, Kryštof ; Kováč, Daniel (referee) ; Mekyska, Jiří (advisor)
Lewy bodies diseases (one of the most common neurodegenerative disorders) have the same pathological basis, but the individual representatives differ in their clinical manifestations. Different diseases affect the mental or physical side of the patient to a greater or lesser extent. This work assumes that thanks to the acoustic analysis of speech, it is possible to distinguish individual diseases from one another, because the disorders of the cognitive and motor aspects of a patient reflect in speech in specific ways. The thesis aims to describe the clinical features of the main representatives of the Lewy bodies diseases, to investigate their impact on speech, to propose characterizing acoustic parameters and then to compare their discriminative power. Speech recordings from the CoBeN and preLBD databases are used as input data for the proposed algorithm. Descriptive statistics, Mann-Whitney U test, FDR correction and XGBoost machine learning model using stratified cross-validation and balanced accuracy are used for subsequent evaluation. The result are scripts for the automated calculation of speech parameters from the database and their evaluation. The results of the analysis prove that the selected diseases can really be distinguished from each other and from a healthy control based on the manifestations in speech, already in the prodromal stages.
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Sub-types of hypokinetic dysarthria in patients with moderete Parkinson's disease
Adamják, Adam ; Kováč, Daniel (referee) ; Mekyska, Jiří (advisor)
This final thesis deals with the research of Parkinson's disease, hypokinetic dysarthria, and acoustic and statistical analyses. Hypokinetic dysarthria is a speech disorder that is a typical manifestation of Parkinson's disease, a neurodegenerative disease that affects approximately 2% of the population over the age of 65. The aim of this work is to reveal the subtypes of hypokinetic dysarthria, based on clinical parameters, acoustic analysis, and statistical analysis. In the acoustic analysis, parameters that examine the area of phonation, prosody, articulation, and speech tempo have been implemented. Subsequently, a statistical analysis was processed, thanks to which it was possible to reveal the subtypes of hypokinetic dysarthria.
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Assessing movement of articulatory organs based on acoustic analysis of speech
Novotný, Kryštof ; Galáž, Zoltán (referee) ; Mekyska, Jiří (advisor)
Hypokinetic dysarthria is a motor speech disorder often present during Parkinson’s disease. It affects the speech system, including articulatory abilities. There are several speech parameters describing this domain, so it is suggested to deal with their mutual comparison. This work aims to design and describe an algorithm for calculating the parameters of articulation, adapted for the Czech language, and then compare their discriminative power. The acoustic analysis of speech included in it is done via the Praat program and basic machine learning algorithms such as Expectation-Maximization, Kmeans and linear regression are used for the subsequent data processing. The Mann-Whitney U test and representatives of linear, nonlinear and ensemble machine learning models using cross-validation and balanced accuracy are used for evaluation. The results are scripts for automatic assessment of vowel space area, for calculating articulation parameters and for their evaluation. The outputs of the analysis of two different databases (PARCZ and CoBeN) prove that differences in articulation can indeed be observed between normal and dysarthric speech. Based on the mutual comparison of results, it is therefore proposed in the work which parameters and models of machine learning are being appropriate for further dealing with this issue.
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|
|
Design and realization of the vocal encoder for audio electronics
Milota, Vojtěch ; Šotner, Roman (referee) ; Kratochvíl, Tomáš (advisor)
This work deals with the design of the vocal encoder, a device used for regressive synthesis of a speech signal using an external carrier signal. Work consists of the block chart, its breakdown and following design of all partial circuit solutions, including simulations in the software environment, followed by design of the printed circuit board and realisation of a prototype of the vocal encoder, followed by experimental measurement of its properties.
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Analysis of Speech Signals for the Purpose of Neurological Disorders IT Diagnosis
Mekyska, Jiří ; Dostál, Otto (referee) ; Přibilová, Anna (referee) ; Smékal, Zdeněk (advisor)
This work deals with a design of hypokinetic dysarthria analysis system. Hypokinetic dysarthria is a speech motor dysfunction that is present in approx. 90 % of patients with Parkinson’s disease. The work is mainly focused on parameterization techniques that can be used to diagnose or monitor this disease as well as estimate its progress. Next, features that significantly correlate with subjective tests are found. These features can be used to estimate scores of different scales like Unified Parkinson’s Disease Rating Scale (UPDRS) or Mini–Mental State Examination (MMSE). A protocol of dysarthric speech acquisition is introduced in this work too. In combination with acoustic analysis it can be used to estimate a grade of hypokinetic dysarthria in fields of faciokinesis, phonorespiration and phonetics (correlation with 3F test). Regarding the parameterization, features based on modulation spectrum, inferior colliculus coefficients, bicepstrum, approximate and sample entropy, empirical mode decomposition and singular points are originally introduced in this work. All the designed techniques are integrated into the system concept in way that it can be implemented in a hospital and used for a research on Parkinson’s disease or its evaluation.
|
|
|
Acoustic analysis of sentences complicated for articulation in patients with Parkinson's disease
Kiska, Tomáš ; Smékal, Zdeněk (referee) ; Mekyska, Jiří (advisor)
This work deals with a design of hypokinetic dysarthria analysis system. Hypokinetic dysarthria is a speech motor dysfunction that is present in approx. 90 % of patients with Parkinson’s disease. Next there is described Parkinson's disease and change of the speech signal by this disability. The following describes the symptoms, which are used for the diagnosis of Parkinson's disease (FCR, VSA, VAI, etc.). The work is mainly focused on parameterization techniques that can be used to diagnose or monitor this disease as well as estimate its progress. A protocol of dysarthric speech acquisition is described in this work too. In combination with acoustic analysis it can be used to estimate a grade of hypokinetic dysarthria in fields of faciokinesis, phonorespiration and phonetics (correlation with 3F test). Regarding the parameterization, new features based on method RASTA. The analysis is based on parametrization sentences complicated for articulation. Experimental dataset consists of 101 PD patients with different disease progress and 53 healthy controls. For classification with feature selection have selected method mRMR.
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